Method 50

Ethylene Oxide by GC/ECD

This method describes the sample collection and analysis of ethylene oxide. Samples are collected by drawing a known volume of air through hydrobromic acid-coated charcoal tubes to produce 2-bromoethanol. Following desorption with dimethylformamide (DMF), an aliquot of the sample is derivatized to its (HFBI) heptafluorobutyrylimidazole, and analyzed by gas chromatography using electron capture detection. While this sampling method can give reliable results with careful attention to details, the inherent instability of EtO on charcoal can present serious problems. In addition, the method is not as sensitive as may be necessary for measuring sub-ppm exposure levels.



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Method Data

Hold Times, Preservatives, Preps, Collection, Analytical & Documentation
Holding Time:   Recovery remained above 90.2 after 17 days of storage @ 5°C or ambient temperature in the dark.
Preservatives:   Keep refrigerated or at ambient temperature in the dark..
Required Preps:   The sampling tube consists of a 6-mm OD.× 4-mm ID × 45-mm glass tube packed with two sections of 24% by weight hydrobromic acid-coated charcoal. The front and back sections contain 100 and 50 mg of the coated charcoal respectively.
Collection Method:   Solid sorbent charcoal tubes: 24L @ 0.1L/min.
Analytical Methodology:   GC/ECD
Documentation:   050

Analyte List*

Analyte Formula CAS Number Detection Limit
Ethylene oxide

* The analytes and detection limits listed for each method represent the typical detection limits and analytes reported for that particular method. Keep in mind that analyte lists may vary from laboratory to laboratory. Detection limits may also vary from lab to lab and are dependent upon the sample size, matrix, and any interferences that may be present in the sample.